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The Hidden Shift in Vaginal and Urinary Bacteria After Menopause

This 2025 review maps how declining oestrogen after menopause reduces protective Lactobacillus in both the vaginal and urinary tracts, raising the risk of bacterial vaginosis, recurrent urinary infections, and pelvic floor and gynaecological conditions.

Women's Health, Midlife

This narrative review widens the lens beyond the vagina alone, tracing how oestrogen decline after menopause reshapes both the vaginal and urinary microbiota — tissues that share the same embryonic origin and respond similarly to hormonal change. As protective Lactobacillus recedes and anaerobic bacteria proliferate, the review links this shift to a broader set of conditions than is often discussed together: bacterial vaginosis, recurrent urinary tract infections, pelvic floor disorders, and even associations with periodontal disease and certain gynaecological cancers. The author frames this as an emerging diagnostic and therapeutic area rather than settled science, and as a review it synthesises existing findings rather than generating new data of its own. What it offers well is context: the genitourinary symptoms many women navigate quietly in midlife aren't isolated inconveniences, but part of a connected microbial shift with implications reaching beyond the vagina itself, worth understanding rather than dismissing as "just menopause."

Ovalle A.

Journal of Clinical and Translational Research

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